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Active HIV Research Studies
About this Page
This page hosts a collection of HIV and HIV-related research at the University of California San Diego and affiliated sites. Progress in treatment for HIV, hepatitis C, hepatitis B, tuberculosis, and other related conditions only occurs with the valuable contributions of individuals who enroll in research studies. These clinical research trials help improve the treatment and management of HIV and other infections.
We encourage you to bookmark this page and check back often, as new opportunities to participate in HIV and related research are added frequently.
This page is managed by The HIV Institute at the University of California San Diego. Contact us at hiv@ucsd.edu with any questions, feedback, or recommendations. Please note, inquiries regarding a specific study or sponsoring center should be directed to the contact listed. The HIV Institute does not manage any of these studies.
To see all HIV/AIDS clinical trials at UC San Diego (including those in progress as well as actively enrolling studies), please visit the UC San Diego Health Clinical Trials page.
If you are interested in including a research opportunity on this page, please click the button below to submit details.
*Disclaimer: Each sponsoring center and/or principal investigator is responsible for the studies listed on this website. This includes study preparation, conduct, and administration of a research grant, cooperative agreement, training or public service project, contract, or other sponsored project in compliance with applicable laws and regulations and institutional policy governing the conduct of sponsored research. Contact the indicated party listed below with any study-related questions.
Antiviral Research Center (AVRC)
To enroll in or get more information about one of these clinical trials at the AVRC, please call the Screening Coordinator at (619) 543-3740 or email Marvin Hanashiro at mhanashiro@health.ucsd.edu
Click here to see a full list of the Antiviral Research Center's currently enrolling studies.
CMV-specific HIV-CAR T cells as Immunotherapy for HIV (Research for an HIV Cure)
The primary goal of this trial is to assess the safety of administering autologous CMV/HIV-CAR T cells to people with HIV. This includes a thorough evaluation of potential toxicities, their nature, frequency, severity, timing, and duration.
Click here for more information and eligibility requirements.
HIV
ACTG A5321 (AHRC)
Studying differences and changes over time in HIV reservoirs (groups of HIV-infected cells that 'hide' from anti-HIV medications) and attempting to answer questions about the ways that HIV infection is controlled. This may have to do with a person’s viral load and CD4 count, when they started their anti-HIV medications, and genetic factors.
Click here for more information and eligibility requirements.
HIV
ACTG 5386 (N-803 with or without bNAbs for HIV-1 control in participants living with HIV-1 on suppressive ART)
Scientists are looking for ways to effectively clear HIV that rests in areas of the body where standard antiretroviral treatment (ART) is unable to reach. IL-15 superagonist (N-803) appears to reactivate HIV that is "asleep" and is also thought to increase the body's natural immune response to HIV. Broadly neutralizing antibodies (bNAbs), such as 10-1074 and VRC07-523LS, have been shown to control growth of HIV in the blood and to increase the body's immune response to HIV. N-803 alone or in combination with bNAbs may provide greater control of HIV than previous efforts.
Click here for more information and eligibility requirements.
HIV
ACTG 5403 (GET IT RIgHT)
The purpose of this study is to determine the best combo of antiretroviral therapy for transgender women (TW) living with HIV who take feminization hormonal therapy (FHT). All participants will receive FHT. The study will determine if TW remain undetectable while receiving FHT for 48 weeks. Additionally, it will assess if hormone levels change based on the type of HIV medications taken.Click here for more information and eligibility requirements.
HIV
DEPTH (Doxycycline for Emphysema in People Living with HIV)
This is a research study to evaluate if the medication doxycycline, a commonly used antibiotic, can slow the damage to the lungs caused by emphysema in people who also have HIV. Emphysema is more prevalent in people living with HIV and may progress faster than in HIV-negative individuals.
Click here for more information and eligibility requirements.
HIV
LAST GIFT
People at the end of their lives often have a unique perspective on life, death and altruism, and may hold the keys to curing HIV. This study takes the next steps in finding a cure for HIV by understanding how reservoirs are distributed throughout the body.
Click here for more information and eligibility requirements.
HIV
TRUVIAN
This research study seeks to test the performance of an investigational blood analyzer to make routine health tests convenient and get results fast. Eligible participants will receive $40 as compensation for a clinic visit and blood draw.
Click here for more information and eligibility requirements.
PURPOSE-3 (Injectable PrEP Study)
We are conducting a clinical study to see whether an investigational twice-a-year injection medication can help reduce the risk of getting HIV from sex.
Click here for more information and eligibility requirements.
HIV SEXUAL HEALTH
PURPOSE-4 (Injectable PrEP Study)
We are conducting a clinical study to see whether an investigational twice-a-year injection medication can help reduce the risk of getting HIV among people who inject drugs.
Click here for more information and eligibility requirements.
HIV SEXUAL HEALTH
HIV Neurobehavioral Research Program (HNRP)
To enroll in or get more information about research studies at the HNRP, please call (619) 543-5000 and ask to speak with a research recruiter.
You may be eligible to participate if you:
•are at least 18 years old
•are HIV+ or HIV- (do not have HIV)
•do or do not have a history of substance use
For participating you will receive:
•Monetary compensation
•Lab results (at no cost to you)
•Medical and psychological test results (upon request at no cost to you)
*All information obtained during the study is kept strictly confidential.
iSTEP - an mHealth Physical Activity and Diet Intervention for Persons With HIV
Summary: HIV is associated with a pattern of neurocognitive deficits, metabolic dysfunction, and an elevated risk for cardiovascular disease (CVD), phenomena that remain untreated despite the use of medications to control the disease. This proposal will examine the effect of a personalized, automated, interactive mobile phone text message intervention (iSTEP) designed to increase moderate physical activity (PA), decrease sedentary behavior (SB), and promote a healthy Mediterranean-style diet (MedDiet) in persons living with HIV (PLWH). The investigators propose that participants who receive the iSTEP intervention will increase the amount of physical activity, improve their diet, show a reduction in risk factors for CVD, and exhibit improved neurocognitive performance.
Click here for more information and eligibility requirements
HIV
DETECT: A novel device to assess how HIV affects neurocognitive decline and postural instability in older adults at risk for Alzheimer's Disease
This is a research study to determine if a brief virtual reality (VR) assessment among older adults living with HIV can help us better screen for changes in cognition and balance.
Click here to download information on this study
Email: hnrprecruitment@ucsd.edu for more information or if you are interested in enrolling
HIV
Biomarkers of Resilience and injury related to HIV and Methamphetamine (BRIHM)
This project will look at METH and HIV-associated biomarker signatures of CNS injury and resilience and will translate them to the clinical environment.
Click here to download information on this study
Email hnrprecruitment@ucsd.edu for more information or if you are interested in enrolling
HIV
Cross-species studies of smoking effects on cognition and neuroinflammation in HIV
This study will examine how smoking affects people living with HIV, specifically the function and performance of the brain.
Click here to download information on this study
Email: hnrprecruitment@ucsd.edu for more information or if you are interested in enrolling
HIV
Mother Child Adolescent Program (MCAP)
To enroll or get more information about one of these IMPACT studies at MCAP, please email Study Coordinator: Alejandra Leon at a5leon@health.ucsd.edu
Owen Clinic
Check back soon for clinical trial updates for Owen Clinic.
Other UC San Diego HIV Research Studies
iSEE Study
iSee is a dissertation study for black women. Individuals can be- English speaking, 18 years of age and older, self-identify as Black/African American, self-identify as a woman, and receive compensation for their participation. View the enrollment flyer.
HIV
Women SHINE is a research study aimed at helping women living with HIV to access and stay engaged in HIV care. Women SHINE is currently enrolling women living with HIV who have experienced violence during their adult life. View enrollment flyer
Enrollment: Now
HIV